Melatonin PR (Prolonged Release) tablets contain 3 mg of highest purity melatonin produced under Good Manufacturing Practices (GMP) pharmaceutical standards. A natural vegetable stearine base ensures a steady intestinal release of easily absorbable melatonin spread out over approximately three hours.
Melatonin is a natural hormone nutrient that is synthesized from the amino acid tryptophan by the pineal gland in the back of the brain. Melatonin also occurs in small amounts in a variety of foods. In the body, melatonin appears to regulate sleep/wake cycles, support normal immune function, and protect cells from free radical damage.
Most of the research on melatonin has focused on its role in maintaining normal sleep/wake rhythms. The perception of daylight in the eyes is a signal for the pineal gland to inhibit melatonin synthesis and release. At night or in the dark, the body’s melatonin production rises. The rise in plasma melatonin is thought to be responsible for bringing on sleep. Nocturnal melatonin production is highest in children and begins to decline from adolescence on until it is virtually absent in the elderly.
Melatonin supports normal immune function by helping maintain the activity of circulating natural killer cells. It also has been found to function as an antagonist for stress-induced immunosuppression.
Melatonin is considered to have potent antioxidant activity. It enters all body cells and is believed to help prevent free radical damage. In the brain, melatonin has perhaps the most important physiological antioxidant of any molecule. Due to its lipid- and water-soluble properties, it can freely cross the blood –brain barrier. In vitro studies show that melatonin is more effective than glutathione in scavenging toxic hydroxyl radicals, and also more efficient than vitamin E in neutralizing peroxyl radicals which can induce DNA damage. Furthermore, melatonin stimulates the main antioxidant enzyme of the brain, glutathione peroxidase.
Serving size: 1 tablet
Servings per container: 60
Adults take 1 tablet (3 mg) 1 hour before bedtime. Increase by 3 mg every four days until reaching 21 mg, or take as recommended by your healthcare professional.
Not to be taken by individuals under the age of 18. If you are pregnant, nursing, taking any prescription medication (especially hormone replacement therapy), or have an autoimmune or depressive disorder consult a physician before using this product. Long-term use of melatonin has not been studied. Use of this product could cause hypothermia. Do not use before or while operating a motor vehicle or heavy machinery.